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KMID : 0895820180280030039
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Journal of Oriental Rehabilitation Medicine
2018 Volume.28 No. 3 p.39 ~ p.53
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Review of the Studies on the Influence of Experimental Arthritis Model of Herbal Medicine Extract
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Park Jong-Han
Jeong Su-Hyeon
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Abstract
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Objectives: The aim of this study was to analyze the herbal prescription and composition of the leading experimental studies of herbal medicine extract in arthritis model and to analyze the way of setting model and the way of validating effect of the leading experimental studies of herbal medicine extract in arthritis model.
Methods: The Subjects were selected by select criteria and exclusion criteria from January 1, 2000 to September 30, 2017. The herbal prescription and composition of the selected subjects were analyzed. The effects and statistical significance of selected studies were verified by comparing the control and treatment groups of frequently used cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6).
Results: 52 kinds of herbal prescriptions and 118 kinds of individual herbs were used in 64 studies. Among the 52 kinds of herbal prescriptions, Daeganghwal-tang (4 times) was used most frequently. Among the 118 kinds of individual herbs, Glycyrrhizae Radix (49 times), Angelicae Giantis Radix (34 times), Osterici Radix (24 times) were used most frequently in order. The prescription that has the highest TNF-α decline is Changchooldoin-tang. The prescription that has the highest IL-1β decline is Banggibokryeong-tang. The prescription that has the highest IL-6 decline is Gwanjeol8ho-bang.
Conclusions: Daeganghwal-tang (herbal prescription) and Glycyrrhizae Radix, Angelicae Giantis Radix, Osterici Radix (individual herbs) were used most frequently. The prescriptions that have the highest cytokines decline were Changchooldoin-tang, Banggibokryeong-tang and Gwanjeol8ho-bang.
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KEYWORD
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Arthritis, Herbal medicine, Tumor necrosis factor, Interleukins
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